I Advice - Health and Fitness

Women who suffer from endometriosis often find out that their condition is more problematic than they thought. Besides having to suffer from painful and heavy monthly periods, discomfort with sex and bowel movem

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ents, another possible negative side effect with endometriosis is weight gain. More and more women today are looking for ways to overcome endometriosis and it’s troublesome side effects.

Endometriosis and Weigh

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t Gain

Few women realize that endometriosis treatment can lead to weight gain. This can be caused by three of the most popular types of medication used for treating endometriosis.

• Danazol — The pituitary gla

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

d is one of the parts of the body that releases hormones. Danazol works by causing blockage to the production and release of FSH and LH hormones. This results to a temporary cease of your menstrual cycle that wi

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ll last from a quarter to three-quarters of a year. Side effects include weight gain, oily skin and tiredness

• Birth Control Pills — Contraceptives can also work as a hormonal treatment to overcome endometrios

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s. The type and frequency of birth control pills that one should take will generally depend on your doctor’s advice. Contraceptives work by regulating the progesterone and estrogen levels in your body. Again, th

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

is leads to a temporary stop to your monthly flow. If you choose to make this treatment permanent, your doctor might advise a gradual increase of frequency or dosage. Again weight gain is a side effect of this t

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

reatment, along with nausea and blood clots.

• Progestins — This medication results to a temporary stop to your ovulation and hinders growth of endometrial cells. This too comes with a number of side effects of

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

which weight gain is one of them.

Prevent Weight Gain Caused by Medication

It’s frustrating to women that the medicines that are supposed to help our symptoms also cause some unpleasant side effects. One of th

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e most troublesome is the weight gain that often comes with the medication you’re taking. Here are some things you can do to keep your weight under control.

Exercise— This may be a simple solution, and even an

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

bvious one at that, but its effectiveness cannot be denied. Exercising can counter the weight gain side effect of your medication. Besides that, exercise can also reduce the severity of symptoms of endometriosis

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

as it blocks the production of estrogen and releases endorphins into the system.

Change Medication — There are other hormonal treatments that you can take that don’t have the weight gain side effect. Consider

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

GnRH-agonists. These drugs treat endometriosis by releasing modified hormones that can stop production of estrogen and consequently cause a temporary cease to your menstrual cycle. The course of treatment lasts

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

or around 6 months and the benefits can be felt for up to a further 6 months. Although weight gain is not a side effect there is the possibility of hot flashes, vaginal dryness and a loss of bone density during

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

treatment, this is usually regained after stopping treatment.

Use of Natural Treatments — Of course, you also have the option of doing away with medical treatments all together and going for something more natu

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

al. You can treat endometriosis in a variety of ways such as taking herbal remedies, using stress-management and relaxation techniques, acupuncture, or contrast sitz baths. Talk to your doctor before stopping an

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

y prescribed treatment and inform them of your decision.

Modify Your Diet — If you wish to continue using the above-mentioned medication, you can still prevent yourself from gaining weight by proactively modify

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ing your diet. Even if your medication does have this particular side effect, it won’t be able to increase your weight too much if you’re eating the right kinds of foods. Avoid eating processed, fried and sweet

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

oods and chose a diet made up of fresh fruits and vegetables and lean meats and fish. Sign up below for the free newsletter that has many more suggestions for natural endometriosis treatments that you can use a

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

longside traditional forms of treatment. There are many ways for you to overcome endometriosis without gaining weight, but be aware that most of them will require some work on your part to keep your figure slim

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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