I Advice - Health and Fitness

“Life is like a box of chocolates,” drawled Forrest Gump.

Metaphors are great. Writers use them all the time because, simply put, they get you

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

r attention and really drive a point home.

That’s because life and a box of chocolates have as much in common as French Toast for breakfast an

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

d a French Toast to your health.

But you know a punch line is coming to connect the dots and relate two ridiculously unrelated things. So you

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

wait, listening sharply to catch the thread that makes it make sense.

“You never know what you are going to get.” Aaahhh, riiigghhtt!

The mis

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

match, mental twisting, and surprise resolution slam the point home. There. That’s the micro-anatomy of our most common literary tool. So how a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

bout a metaphor for eating healthy?

Losing weight is like eating a single scoop death-by-chocolate ice cream cone. Okay, that nailed the “man,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

this strains reason” part. But now let me explain.

First of all, real connoisseurs know that you must linger over your ice cream: chasing run

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ers, keeping it off the pavement, and pushing it right to the bottom of the cone without bathing in it. These are all vital factors. It’s a pro

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

cess.

And that’s the point. It just takes time, and when you’re finished with that ball, you think … perfect!

Now imagine that same single sc

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

oop of ice cream, but this time placed in the deep empty hollow of a cereal bowl. We see it down there, sad and lonely, and invariably decide t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

hat it needs 3 more scoop buddies.

That’s because we believe we are getting gypped somehow if our food doesn’t fill the space.

Now. What does

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

this have to do your dinner tonight? Well, the space you serve your food in matters. If you put dinner on a gigantic platter, you’ll end up wi

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

th helpings 2, 3, and 4 on the plate all at the same time. And if it’s in front of you … you’re going to eat it.

So a basic message you can ta

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ke home and try tonight is simply to begin on smaller plates. This trick exploits one of the bedrock laws of the Universe.

There’s four of the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

in all: E=MC2, Finder’s Keeper’s, The Conservation of Matter and Energy, and the big one – Your Eyes Are Bigger Than Your Stomach.

Simply han

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

dling this last law prevents the drastic overeating so typical of American buffet trough-feeders. And, repealing this law of nature doesn’t req

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

uire any higher math or even a physics degree.

Take the first step to solving your portion problems by beginning with a smaller space for your

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

food. Next, eat your food like you eat your ice cream – a little at a time. Enjoy it by making it last.

Small bites increase the length and p

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

leasure of the meal. When your focus is more on enjoyment than consumption, that smaller amount becomes … perfect!

Your calories drop with you

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

r portion sizes and you love your food more – just like lingering over your single scoop death-by-chocolate ice cream cone!

Aaahhh, riiigghhtt

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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