I Advice - Health and Fitness

There is a word that most overweight people dislike, it is a word that turns people off and makes their mind switch to another channel to avoid thinki

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ng about it.

Unfortunately it is a key part to weight reduction and something that when done correctly can be the cause of your success.

The word is

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

…………..

Exercise!

Now stay with me here, switch your mind back on to what I am saying stay, in this same frame.

The reason most overweight people do

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

not like the ‘E’ word is because they have set up in their mind that in equals pain and like most people they will do anything to avoid pain. There is

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

a better way and you can find the better way when you begin to understand that there are different ‘types’ of exercise (hey, don’t disappear – stay wi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

h me now).

At the lowest level there are 2 forms of exercise, these are;

· Aerobic

and

· Anaerobic

Aerobic exercise causes your heart and muscles

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

to work very hard, pumping blood round your body at a high rate to get the oxygen to the muscles in order for them to keep working. A side effect of

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

his is that it produces acid in your muscles, lactic acid to be precise. It is this lactic acid that causes you muscles to stiffen up after you have f

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nished, causing you pain. Lactic acid also stays in your system for a long time as your body finds it hard to break it down. If your body cannot break

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

the acid down it wraps it up and stores it as fat!

The main type of aerobic exercise that people do on a regular basis is running, yes this helps bui

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

d fitness but if you want to reduce your weight you can only concentrate on building fitness once you get down to a sufficient weight. What you shoul

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

d concentrate on to start with is reducing your weight and nothing else, fitness comes later.

This is where anaerobic exercise comes in.

Anaerobic e

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ercise causes the heart to work harder than normal which still pushes the blood and oxygen around the body but does not work the muscles as hard and t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

erefore does not create lactic acid. Further more anaerobic exercise helps in releasing stored fat and acid and helps it into the waste system so tha

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the body can get rid of it. Remember you cannot ‘burn’ off your weight. The phrase ‘burning off calories’ is a myth!

The weight you get rid of has t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

leave your body somehow and it is through your waste system that this happens.

So, what is the best form of anaerobic exercise? I hear you ask

Well

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

as the title of this article suggests it is walking.

My suggestion to you is that you walk for 1 ? hours at least 3 times per week and that should b

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

broken down into the following;

· 15 minutes warm up walking at a pace slightly faster than your normal walking pace

· 60 minutes walking at a high

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

pace that gets your heart pumping

· 15 minutes warm down walking at your normal walking pace.

If you cannot manage that to start with find your own

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

evel and start there and slowly build up to this level.

Remember the warm up and warm down though as this is vital.

Enjoy your walking.

Yours truly

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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