I Advice - Health and Fitness

In recent years, a number of companies have introduced liquid vitamin supplements, some of them claiming that these products far outperfor

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

m the traditional vitamin pill. While some companies took their claims too far (and were charged accordingly), the debate continues as to

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

which type of vitamin is the most effective.

The main advantage of a liquid supplement is the speed and ease of absorption by the body. S

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nce there is no need to break down a solid, the vitamins are absorbed immediately. Liquid fans also claim that the absorption rate is much

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

higher, making the supplements more effective.

There are also those who hate swallowing big vitamin pills or simply can't swallow them d

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e to a medical condition. For instance, people who have had gastric bypass surgery find it hard to keep a pill down. Throat surgery can al

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

so make swallowing solids painful. For people like this, liquid vitamins are the only viable option.

But liquid supplements have their dr

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

awbacks. One of the main problems is that the vitamins and minerals do not keep their potency as well in liquid form. That means that the

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

iquids have a shorter shelf life than pills.

There are also enzymes contained in some vitamin tablets that aid in the absorption of the n

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

utrients. These enzymes can't be included in liquid vitamins because they only last for a day or so in liquids. While with pills, the enzy

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

es retain their effectiveness for the entire shelf life of the products.

The claim of faster and more complete absorption of liquids is a

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

lso challenged by some experts. While it's true that we digest liquids more quickly than solids, this does not necessarily lead to a more

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

effective product.

The most effective place for vitamin absorption is at the beginning of the small intestine. There are some claims that

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

much of the contents of liquid vitamins is destroyed by stomach acids before it even gets this far. Pills, meanwhile, are coated to keep t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

hem from dissolving completely before they reach the small intestine.

While we live in a world where immediate effects are usually consid

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

red a good thing, their relevance for vitamins is questionable. After all, our bodies don't suddenly have vitamin emergencies. If one vita

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

min supplement is absorbed into our systems an hour sooner than another, it's unlikely to have any noticeable effect on our overall health

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

.

When it comes to our health, nobody likes to guess what is best. But until enough time has passed to show for certain whether there is

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

difference between the effects of liquid and tablet vitamins, you'll simply have to go with the one that makes the most sense for you. As

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

long as you are focused on a healthy lifestyle and good nutrition, the format of your vitamin supplement shouldn't be a critical decision

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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