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I Advice - How To Stop Your Snoring - 3
So…Just What the Heck is Snoring, Anyway?
Technically, snoring is defined as any resonant noise from the respiratory tract that emerges during sleep.
Biologically, snoring refers to a vibration in the airway connecting the nose
Technically, snoring is defined as any resonant noise from the respiratory tract that emerges during sleep.
Biologically, snoring refers to a vibration in the airway connecting the nose
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
and the mouth; a vibration that can emerge through the mouth, the nose, or (as some non-snorers are painfully aware), it can emerge through both!
As you can sense, the more narrow the airway, generally speaking, the more intense
As you can sense, the more narrow the airway, generally speaking, the more intense
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
he vibration; and ultimately, the louder the snore.
You may also be wondering why snoring only seems to emerge at night; after all, people literally use their airway every moment of their life; so why is snoring a nocturnal dilem
You may also be wondering why snoring only seems to emerge at night; after all, people literally use their airway every moment of their life; so why is snoring a nocturnal dilem
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
a?
The answer to this is found in looking at the tissues within the airway. This tissue is very soft, and at night becomes relaxed; its similar to how some muscles, like biceps, become relaxed at night since the body does not re
The answer to this is found in looking at the tissues within the airway. This tissue is very soft, and at night becomes relaxed; its similar to how some muscles, like biceps, become relaxed at night since the body does not re
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
quire them.
As the throat (and its subsequent tissue) relaxes during sleep, the wind tunnel/airway becomes narrower and hence, snoring occurs.
Why Do Some People Snore Louder than Others?
This, too, is the reason why some peopl
As the throat (and its subsequent tissue) relaxes during sleep, the wind tunnel/airway becomes narrower and hence, snoring occurs.
Why Do Some People Snore Louder than Others?
This, too, is the reason why some peopl
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
snore louder than others; and why the actual tone and pitch of one snorer may be rather different than another.
The actual snoring sound that emerges is dependant upon the force of wind that is being pushed through the (narrowed
The actual snoring sound that emerges is dependant upon the force of wind that is being pushed through the (narrowed
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
airway. As you can envision, the more potent the force of wind (i.e. the faster the speed of the wind), the louder the snoring.
This is also why even babies can snore; but its often not considered snoring in the conventional se
This is also why even babies can snore; but its often not considered snoring in the conventional se
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
nse, because an infants force of wind through their wind tunnel is so mild, that it can easily be ignored (though this can lead to complications; infant snoring can often be a symptom for a breathing and/or respiration problem, in
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
luding allergy).
However, while snoring affects people of both genders and of all ages, it typically does afflict more men than women. There are a few reasons for this.
Snoring Tends to Favor Men
Overall, mens necks tend to be
However, while snoring affects people of both genders and of all ages, it typically does afflict more men than women. There are a few reasons for this.
Snoring Tends to Favor Men
Overall, mens necks tend to be
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
larger than womens necks; and thus there may be more fleshy tissue in there just waiting to combine with air flow and cause snoring.
Another reason is that women produce the hormone called Progesterone, which is considered by som
Another reason is that women produce the hormone called Progesterone, which is considered by som
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
medical experts to be an aid in reducing or preventing snoring. In fact, there are some anti-snoring treatments that involve Progesterone therapy for snoring men.
Factors that Increase and/or Lead to Snoring
There are several
There are several
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
health and lifestyle factors that contribute to snoring; and this is true for both men and women, since snoring is a condition that does affect both genders (though surveys suggest that men snorers outnumber women snorers by a rat
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
o of 2:1).
Some of the major health and lifestyle factors that can contribute to snoring include:
< Allergies, which can clog the airway and trachea
< Allergy medications, which can dry the nasal cavities
<
Some of the major health and lifestyle factors that can contribute to snoring include:
< Allergies, which can clog the airway and trachea
< Allergy medications, which can dry the nasal cavities
<
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Cold and Flu, which can similarly clog the airway (this is why some people experience snoring only when theyre suffering a cold or flu)
< Thickened tissues in the nasal passages, which can sometimes result from some surge
< Thickened tissues in the nasal passages, which can sometimes result from some surge
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
ries unrelated to snoring
< Overuse of nasal sprays which irritate the nasal passageway
< Enlarged adenoids and/or tonsils
< Goiter (swelling of the an ineffective thyroid gland in the neck)
< A dis
< Overuse of nasal sprays which irritate the nasal passageway
< Enlarged adenoids and/or tonsils
< Goiter (swelling of the an ineffective thyroid gland in the neck)
< A dis
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
roportionately large tongue that blocks airflow
< Ineffective regulation and neural control of mucus membranes
< Obesity and excess weight (leading to an enlarged neck and excess soft tissue in the trachea)*
<
< Ineffective regulation and neural control of mucus membranes
< Obesity and excess weight (leading to an enlarged neck and excess soft tissue in the trachea)*
<
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
Excess gut/belly (relatively decreasing the size of the lungs)*
< Drinking alcohol**, which:
o sedates the throat muscles and causes them to collapse o dilates blood vessels which swells up throat tissue
< Drinking alcohol**, which:
o sedates the throat muscles and causes them to collapse o dilates blood vessels which swells up throat tissue
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
< Cigarette smoking, which inflames the upper airway
< The normal aging process, which can simply lead to a loss of muscle tone in the neck and thus snoring
* Since relatively more men tend to experience an exces
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
gut, this is one reason why more men tend to experience snoring than women.
** Any medication (prescribed, over the counter, or illicit) that leads to excessive relaxation can lead to snoring.
So while we've looked at what snor
** Any medication (prescribed, over the counter, or illicit) that leads to excessive relaxation can lead to snoring.
So while we've looked at what snor
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
ng is, and what (rather common) factors and variables lead to/increase snoring, there still remains a very important element to focus upon: just how devastating is snoring? I answer this rather ominous question in my next article
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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