I Advice - Health and Fitness

What the heck are free radicals and just what do they have to do with your skin? You may have heard about free radicals from a cosmetics sales clerk or on a television commercial and writte

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

n them off as complete rubbish. After all, hearing all this free radical talk about little molecules doing damage to your skin? How silly!

Actually, it is very likely. Granted, some cosmet

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ics companies may over-hype the damage free radicals do, but the truth is that free radicals exist and they are aiding in the damage done to your skin. As if UV rays from sunlight, harsh we

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ther conditions, and too many cosmetics were not enough! Now you have to worry about damage at an atomic level too? It almost seems like there is no relief from skin damaging elements.

Bef

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ore you can begin to help your skin, you probably want to know just what this free radical hullabaloo actually is. Free radicals are highly reactive molecules that have unsatisfied electron

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

valence pairs. If you remember from your high school science class, an atom has protons, neutrons, and electrons.

Normally, electrons in an atom will be paired up, but in some cases, such

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

as with oxygen, the atoms will go through chemical reactions and through the reaction, one or more electrons can be lost, leaving the atom without its usual number of electrons. The oxygen

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

molecule now begins searching out another molecule in order to swipe the electron it needs to be even again. This molecule is the free radical, doing damage as it bounces around, trying to

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

steal back electrons.

The chain of free radicals is virtually unending, as one molecule snatches up an electron from another, that molecule must now go on a search for an electron, and so

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

orth. These unstable molecules are what cause damage to our skin. The theory is that free radicals searching for stability through taking other electrons cause skin cells to break down. Ski

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

n cells that have broken down lose their ability, or have their ability hampered, to function as they normally would. This damage can cause winkling and other skin issues.

Fabulous, but ho

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

w do you stop all these crazy free radicals? The answer is already out there; antioxidants. Antioxidants occur everywhere naturally, not just in your skincare products. The purpose of antio

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

idants is to take up free radical oxygen molecules and prevent them from stealing electrons from other molecules, thus helping to stop the chain of free radical destruction.

There are many

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

antioxidants out there, either in natural elements, or as man-made creations. Green tea and other teas have been found to have great antioxidant properties and have been used for some time

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

for that very reason.

Remember, antioxidant is not an ingredient you will find in your skin care products. Instead, that is the function that certain ingredients will perform for you. So

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

f you begin looking for a moisturizer or other product and are searching the ingredient list for the word antioxidant, you are not going to find it. Instead, you should find out what ingred

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ients offer antioxidant capabilities and look for those in the products.

Antioxidants are in just about every moisturizer on the market these days, so you should not have much trouble find

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ing one. Even if you buy or have been using a product with antioxidants, do not expect to see some kind of miraculous improvement in your skin. Antioxidants are only meant to help stop free

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

radical damage, not repair it.

They are not going to suddenly make winkles disappear or to make your skin suddenly moisturized. There are other ingredients in the product you choose that c

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

an do such things, as they are meant to. Antioxidants are simply there to neutralize free radicals, but that should be no less important when looking to give your skin some extra protection

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Does your business need funding to grow? Read this article to learn about some little known (but widely used!) options.

Financial decisions are very important to the health of any company. They can affect your reputation also. So it is critical that decisions are made using the best techniques available. Cost Benefit Analysis is designed to help you make the best financial decision possible. To make the best decision though, you need to follow the guidelines. These are some commonly made mistakes that you need to avoid.

Oftentimes workouts at home tend to focus on aerobic and strength training exercises in order to improve physical conditioning, and there is no doubt that such a program can be effective for many. But another key ingredient of physical health can go unnoticed if you aren't careful and that is flexibility of the muscle groups of your body. Strong muscles that aren't flexible can be prone to injury, so pilates exercises help round out a good home fitness exercise routine.

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