I Advice - Health and Fitness

The icy winter winds work havoc with your skin, and chapping of skin becomes a common problem. But, the most vulnerable to cold is dry skin which cracks easily if un-cared for. Many a time cracked skin bleeds too. It is, therefore, neces

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

sary to avoid exposure. Also you have to take care of other parts of your body like palms, feet, back and neck, etc. Icy winds also fade the complexion of your skin. If the skin is dry, then minimize the use of soap to as little as possi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ble. Cold cream and olive oil are effective in reducing dryness. But, before this it is essential to deep-cleanse your face. For deep-cleansing, take a cotton swab, dip it in water and squeeze it. Apply cleansing-milk and rub it thorough

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ly on your face and neck. Do not use unheated milk which might result in opening up unwanted pores on face. Tomato and raspberry juice is best suited for facial cleaning. At night, do not use water after cleansing, but use wet towel for

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

iping. The towel should be drenched in hot water and then squeezed. After this, facial massage with skin-tonic mixed with almond oil is beneficial. Massage should be continued for at least ten minutes so as to enable the cream to penetra

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

te the skin.

Skin-tonic can be either bought from the market or prepared at home. For homemade tonic-take fifty gm. of marigold petals, soak them in a half litre water in a stainless steel pot and warm it on heater. Keep the flame low.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Keep lid on the pot so that the steam does not escape. Now take pure wax, melt it and mix it with the mixture of marigold and heat it on a medium flame for half an hour. When the cream gets cold, fill it in a bottle. This is your skin-to

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ic. Cold cream is much in use during winter. For homemade cold cream-peel a cucumber and cut it into small pieces. Take four parts of almond oil, one part pure wax and put it on low heat When the two get mixed completely then add pieces

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

of cucumber and heat on a low flame for forty-five minutes. The cucumber pieces should be onefourth of the mixture. Stir slowly while heating. You may add a little perfume for fragrance.

During winter, dry skin regains its glow by mass

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

aging. Massage hands, arms and other exposed parts of the body with 'hand lotion'. It prevents skin from chapping while working in kitchen. 'Hand lotion' can be prepared by mixing lemon juice in rose water. 'Milk cream' should be applied

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

on wrist and fingers to keep them soft. Dryness of skin can be removed by a massage with olive oil, or mustard oil or almond oil followed by a sun bath. A little after sun bath water bath with luke-warm water should be taken which helps

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

in removing tiredness; and it also increases blood circulation in the veins. To prevent the lips from chapping, a light application of cold cream or vaseline on the lips is essential before going to bed. Using chap stick also helps.

Fol

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

lowing are some of the measures to protect the skin in winter:

Do not use soap. If your skin is oily, then wash your face with soap only once a day. Cleansing-cream must be used on face in case of a dry skin. For oily skin use skin-to

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nic. Do not wash your face with very hot water. Use of moisturizer reduces dryness of the skin. Do not forget to massage your face with cold cream or skin-tonic before going to bed. Use as little make-up as possible if you have pimple

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

. Dry, cold winds of winter often chap the skin. To guard against it, make a paste by adding white flour to milk and rub it well on face. Dirt and dust will come out with the maida paste leaving the skin soft.

If you have a dry and ro

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ugh skin, take the seeds of watermelon, pumpkin, cucumber and kharbuja (known as charon-magaz) in equal quantity, grind them in milk. Make a paste adding fresh milk cream. Apply it on your face. Leave it for one hour and then wash it o

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ff. Take mustard seeds. Clean them and grind. Make a paste either in milk or water. Daily use of this paste is good to give glow to the skin. Mix water and vinegar in equal quantity. Apply it on your face with a cotton swab.

If the skin

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

is dry, use cold cream for a light massage. Add a spoonful of olive oil to a bucket of water for your bath. This also gives a glow to the skin. If the skin is very dry, massage with warm olive oil fifteen minutes prior to bath. In summ

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

er protect yourself from hot winds of the heat-wave by applying on your face lime water mixed with milk oil in equal quantity. Keep it for fifteen minutes. Beware, that it does not go into your eyes. For dry skin, a very useful solution

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

can be made thus: Take a spoonful of almond oil, ten spoonfuls of un-boiled milk and a pinch of sugar. Mix and beat the mixture well. Apply it on face with a swab of cotton. Let it remain for fifteen minutes. Wash it off with tepid water

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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