I Advice - Health and Fitness

A starvation diet in my mind is any diet where you are starving yourself. I know that when we are dieting usually we will restrict our c

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

alories so that we are burning more calories than we eat but on a starvation diet we are actually restricting calories to such a point t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

hat we affect our metabolism and force our bodies to jump into a phase below dieting where we are not able to lose weight anymore.

To u

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nderstand a starvation diet we need to look at what we are doing to our body when if we decide not to eat at all for a few days. First o

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

f all our bodies will think that we are just between meals and our body will start to use up blood sugar and then start burning up carbs

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

until they are gone. Once we have run out of carbs our body should use fat and muscle tissue for energy but instead will start to lower

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

our metabolism in a fight to protect our bodies…this is the starvation phase. Eventually if we did not eat our bodies would start to bu

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rn off our fat and muscle and our metabolism would slow to a point where we would become very lethargic and our organs would start to sl

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ow down and eventually shut down and we would die. There are not many people that would go this far bad as we see in people with bulimia

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

this definitely does happen sometimes.

Instead of using a starvation diet to lose weight what most diets tend to do is to confuse the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

mind and body so that our metabolism well stay up and will continue to burn fat while at the same time hopefully not burning the muscle

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

that we have nearly as quickly. If we look at bodybuilders in their dieting phase before a competition they must lose all of their fat s

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

o they have to diet fairly hard and expect to lose some of their muscle – actually quite a bit of muscle.

When you are looking at a die

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t and do not want to starve look at the following points.

1. What is the goal of your diet? Usually the goal is to lose fat
2. Wha

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

t are you going to do to lose that fat? If you diet your body needs to stay a little bit comfortable and if your try to lose weight too

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

fast you will go into starvation mode.
3. What are you going to do to raise your metabolism? Most people will use exercise for two

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

reasons, firstly the exercise will burn calories to help you lose weight, but even more importantly getting exercise will force your bod

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

y to raise your metabolism so that it can be ready when more exercise is going to happen.

In reading this hopefully you will see your b

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ody as I do, and that is that our bodies are machines that adjust to stimuli fairly quickly. Your body will speed up and slow down it’s

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

burning of calories and storing of fat. I hope this will help you a little bit in learning to control your body using diet and exercise.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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