I Advice - Health and Fitness

Pain because you injured your knee playing soccer? Are you over 50 and experiencing osteoarthritis pain in your knee? Perhaps you simply stood up incorre

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ctly and twisted your knee? Knee pain, no matter what you did to cause it, can be excruciatingly painful.

Most knee injuries and conditions can be treat

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

d with conservative knee pain therapy. Knee pain therapy can easily be conducted at home; however, it is very important to see your doctor in order to de

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

termine the correct knee pain therapy for you.

Knee Pain Therapy Medications

Knee pain therapy medications include:

• Nonsteroidal Anti-inflammatory D

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ugs (NSAIDs). NSAIDs are painkillers, such as Advil and Motrin. These medications can help alleviate some of the pain and inflammation caused by injury a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

d osteoarthritis in the knee. Most NSAIDs can be bought over the counter, without a prescription. DO NOT use aspirin.

• Opioids. If the pain is unbearab

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

le, some doctors may prescribe opioids as part of a patient’s knee pain therapy. Opioids, otherwise known as narcotics, are usually offered for a brief p

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

riod of time due to dependency issues and negative side effects. They are superior at masking the pain, but do not help reduce inflammation. Great care m

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

st be taken if opioids are prescribed for your knee pain therapy.

• Corticosteroids. When corticosteroids are used as part of your knee pain therapy, th

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ey help minimize inflammation, therefore relieving much of the pain. Corticosteroids can be ingested orally, or injected into the site of inflammation. C

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

rticosteroids can offer immediate pain relief; however serious side effects have been confirmed, such as thinning of the cartilage and ligament weakening

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Corticosteroids must be used with care.

The usual medical explanations for knee pain include arthritis, bursitis, tendonitis, ligament injury, and join

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

cartilage deterioration. MRI’s and other tests often seem to substantiate such diagnoses and while good indicators they are not the holy grail and too o

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ten lead to mistaken diagnoses.

Even in the absence of objective evidence, knee pain alone many times is assumed to be proof that the joint itself is in

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

trouble. This has lead to needless surgery when in fact the surgery was more than likely unnecessary in a large number of cases. Always get a 2nd and 3rd

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

opinion where you knee is involved to have sufficient information to make the “right” decision. After all, it is you knee...and your pain.

Alternative

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

reatments

You should also consider alternative treatments as your knee pain therapy. In 1997, a National Institutes of Health consensus panel determined

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

that acupuncture can actually help treat many types of knee pain, including the pain caused from knee osteoarthritis.

In the meantime, search for Knee P

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ain Info on the Web to find the answers to more of your knee pain therapy questions, and always make sure you read more than one opinion, or rely on no l

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ss than two opinions, including that of your doctor. A 2nd opinion is always useful in helping you make the right treatment choice to eliminate your pain

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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