I Advice - Health and Fitness

One of the most common types of pain is a headache. Many people resort to over-the counter medications to relieve their headache, instead of trying to eliminate the cause of it. Twenty-seven percent of

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

patients with headaches seek alternative forms of therapy, with the most common being chiropractic care. Below is an overview of the most common forms of non-migraine headaches. (For information on mi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

raine headaches, please see the article “What is a Migraine Headache?”)

Tension Headache
These headaches are often worse in the afternoon or early evening. The pain is usually on both sides of the

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

head and/or around the eyes. Tension headaches can last for days or weeks, and come and go over a long period of time. They are occasionally relieved with over-the-counter analgesics. Tender points an

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

tight muscles are usually found in the neck. Deep massage to the muscles at the back of the head and neck helps, as does ultrasound and moist heat to the same area. Supplement options include valerian

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

root and passionflower for stress reduction, and magnesium and calcium for muscle tension.

Cervicogenic Headache
Cervicogenic headaches often present with a reduction in neck motion and associated

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

neck pain. They are due to referral from the soft tissues and joints in the neck. The headache is usually worse with head movement. The primary recommended form of treatment is chiropractic manipulati

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

n of the neck.

Cluster Headache
These headaches, which are felt around the eyes, are more common in middle-aged males. They “cluster” over days or weeks and then end, and appear again several week

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

or months later. Cluster headaches typically begin at the same time each day or night. They are short-lived, lasting an average of 30 minutes, but they are extremely intense. During an attack, there

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

is often tearing and a runny nose on the same side as the headache. There is usually a history of smoking and possible alcohol abuse. The cause of cluster headaches is unknown. Cluster headaches genera

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ly decrease in frequency and intensity as the individual ages. Conservative management includes moist heat, trigger point therapy, ultrasound, and spray-and-stretch to reduce muscle tension; cervical an

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

upper thoracic chiropractic adjustments to decrease contributing joint dysfunction; avoidance of screen glare from computers and televisions; and stress reduction.

Hypertensive Headache
These head

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ches are pulsing and occur early in the morning. They are associated with high blood pressure, obesity, stress, lack of exercise, high sodium diets, drug sensitivity, kidney disease, and heart disease.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Hypertensive headaches come on when blood pressure is 200/120 mm Hg or higher. The headaches can be at the top of the head, the front of the head, or the back of the head, and can be generalized or o

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e-sided. The headache may become worse when reclining and is less severe when seated. Management includes dietary modifications (high fiber, low salt); avoidance of caffeine, high fat, sugar, and alcoh

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

l; and moderate exercise.

Sinus Headaches
These headaches are attributable to inflammation of the mucosa of the sinuses from allergies or bacterial or viral infections. The headache is generally f

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

lt over the forehead and cheeks, and occasionally around the teeth and behind the ears. Sinus headaches are worse in the morning and are aggravated or relieved by head position, which may help or hinder

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nasal drainage. Conservative treatment options include avoiding known allergens, correcting areas of cervical dysfunction that may hinder sinus drainage, and using a vaporizer or hot compresses on the

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ace to clear sinus congestion. Anti-inflammatory herbs such as turmeric, ginger, and feverfew are of some benefit.

References: Souza, Thomas A. Differential Diagnosis and Management for the Chiroprac

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

or: 415-433. Gaithersburg, Maryland: Aspen Publishers, 2001.

Huff, Lew, and David M. Brady. Instant Access to Chiropractic Guideline and Protocols: 12-15. Saint Louis, Missouri: Mosby, Inc., 1999

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.iadvice.org.ua/article/262064/iadvice-NonMigraine-Headaches.html">Non-Migraine Headaches</a>

BB link (for phorums):
[url=http://www.iadvice.org.ua/article/262064/iadvice-NonMigraine-Headaches.html]Non-Migraine Headaches[/url]

MLM, or multi-level marketing, is a legitimate and potentially lucrative way to have your own home based business. By directly selling products while creating your own upline downline, you can work your MLM business part-time, from home, and at in your own hours. Even with all the potential for making money, you should decide, though if an MLM is for you.

In an attempt to understand the situation in Afghanistan better, I interviewed Afghan journalist Daud Khan. The online interview session took place on 27th September, 2006.

Is it possible to stop a locust plague thru use of sound waves, harmonics and acoustic directional sound technologies? First we know that Locust Swarms are intense with as many as 20 million insects ripping thru the countryside eating everything in sight. Indeed these swaths of devastation can be five to twenty square miles wide.

Tags

Links

I Advice - Non-Migraine Headaches

Related Articles: